Insulin Sensitivity in Patients With Atopic Dermatitis (AD-IF)

University Hospital, Gentofte, Copenhagen

Status

Completed

Conditions

Atopic Dermatitis/Eczema

Type 2 Diabetes

Treatments

Diagnostic Test: Hyperinsulinemic euglycemic clamp

Study type

Observational

Funder types

Other

Identifiers

NCT03003793

H-15010198

Details and patient eligibility

About

The incidence of atopic dermatitis and type 2 diabetes, respectively, has increased over many years. Novel research shows an association between the two conditions. While this relationship at least in theory can be explained by lifestyle factors, there is reason to believe that other pathophysiological mechanisms are involved. Hence, our hypothesis is that patients with atopic dermatitis are insulin resistant due to their chronic inflammatory state. Insulin resistance might play an unknown part in the increased frequency of type 2 diabetes among patients with atopic dermatitis. In the present project, the investigators aim to measure insulin sensitivity by means of the 'golden standard' hyperinsulinaemic euglycaemic clamp in patients suffering from atopic dermatitis compared to a healthy control group (matched case-control study). The project is a close collaboration between The Department of Dermatology and Allergy and Center for Diabetes Research at Gentofte Hospital.

Enrollment

32 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Moderate to severe atopic dermatitis for at least 5 years
BMI < 30 kg/m2
HbA1c < 42 mmol/mol

Exclusion criteria

Diabetes
Prediabetes
First-degree relatives with diabetes
Chronic inflammatory diseases other than atopic dermatitis and asthma
Pregnancy
Breast-feeding
Daily intake of medications that are known to influence the glucose metabolism are not allowed one month before the study (e.g. asthma medicines and hormonal contraception).