Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Cairo University (CU)

Status: Completed

Conditions: High Intensity Interval Training; Diet, Healthy

Treatments: Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

Study type: Interventional

Funder types: Other

Identifiers

NCT04830995

Cairo Un100

Details and patient eligibility

About

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Full description

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by "Diamond Diagnostics," while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Enrollment: 40 patients

Sex: Female

Ages: 25 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• forty multigravida females.
• their age ranged between 25 to 35 years old.
• Body mass index (BMI) <30kg/ m².

Exclusion criteria

• females with pelvic pathology as endometriosis.
• females have irregular menstrual cycles.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

diet program

Experimental group

Description:

moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly

Treatment:

Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

high intensity interval training

Experimental group

Description:

high intensity interval training for four weeks, 3 sessions weekly

Treatment:

Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks