Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

University of Southern Denmark (SDU)

Status: Unknown

Conditions: Type2 Diabetes

Treatments: Drug: BQ123 + BQ788; Drug: Insulin clamp; Drug: BQ123

Study type: Interventional

Funder types: Other

Identifiers

NCT04907838

s-20180040

Details and patient eligibility

About

This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.

Enrollment: 22 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Type 2 diabetes OR healthy control (no type 2 diabetes)
• BMI<32

Exclusion criteria

• heart disease
• pregnancy or birth within 3 month
• smoking
• Kidney disease
• beta-blockers
• insulin treatment (for type 2 diabetics)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

Type 2 diabetics

Experimental group

Description:

BQ123 (25 nmol/min), BQ788 (25 nmol/min)

Treatment:

Drug: BQ123 + BQ788

Drug: BQ123

Drug: Insulin clamp

Healthy controls

Experimental group

Description:

BQ123 (25 nmol/min), BQ788 (25 nmol/min)

Treatment:

Drug: BQ123 + BQ788

Drug: BQ123

Drug: Insulin clamp