Insulin Treatment in Cancer Cachexia

Göteborg University

Status and phase: Completed; Phase 4

Conditions: Cancer Cachexia

Treatments: Drug: Insulatard, flexpen

Study type: Interventional

Funder types: Other

Identifiers

NCT00329615

kl450112

Details and patient eligibility

About

The study is designed to evaluate whether daily insulin treatment to weight losing cancer patients attenuates progression of cancer cachexia and improves metabolism.

Full description

Randomized study with long-term follow-up based on survival, health related quality of life, food intake, resting energy expenditure, body composition, exercise capacity and measurement of metabolic efficiency.

Sex: All

Ages: 25 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Weight loss
• Systemic solid cancer

Exclusion criteria

• Diabetes
• Brain metastases
• Expectant survival of less than 6 months
• Serum creatinine above 200 umol/l
• Persistent of recurrent fever
• Cholestasis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)