Intact Vagal Innervation and Glucagon-like Peptide-1 (GLP-1) Effects

University Hospital, Gentofte, Copenhagen

Status: Unknown

Conditions: Vagotomy, Truncal

Treatments: Other: Saline; Drug: GLP-1

Study type: Interventional

Funder types: Other

Identifiers

NCT01176890

Truncated mealtest (AP)

Details and patient eligibility

About

The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of Glucagon-like peptide-1 (GLP-1) in respect to gastric emptying, appetite and food intake.

The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the researchers will investigate individuals with and without intact nervous supply.

Full description

GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of intact vagal innervations on the effect of GLP-1 on the food intake, gastric emptying (GE) and appetite.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• truncal vagotomy
• normal hemoglobin
• informed consent
• Age, gender and weight matched controls
• normal hemoglobin
• informed consent

Exclusion criteria

• type 1 diabetes mellitus or type 2 diabetes mellitus
• body mass index > 30 kg/m2
• inflammatory bowel disease
• intestinal resection
• nephropathy (serum creatinine > 150 µM and/or albuminuria)
• liver disease (ALAT and/or ASAT > 2 x normal value)
• treatment with medicine which cannot be paused for 12 hours

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

Vago

Experimental group

Description:

Truncally vagotomized subjects (due to duodenal ulcer operation)

Treatment:

Drug: GLP-1

Other: Saline

Cardia

Experimental group

Description:

truncally vagotomized subjects (due to esophagus resection)

Treatment:

Drug: GLP-1

Other: Saline

Healthy controls

Experimental group

Description:

Healthy control subjects

Treatment:

Drug: GLP-1

Other: Saline