Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants

Alexandria University

Status: Enrolling

Conditions: Lung Recruitment; Chest Ultrasound; Ventilator Lung; High Frequency Ventilation; Echocardiography

Treatments: Other: Lung recruitment

Study type: Interventional

Funder types: Other

Identifiers

NCT05726578

0201752

Details and patient eligibility

About

The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.

Enrollment: 72 estimated patients

Sex: All

Ages: 1 hour to 3 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infants will be enrolled if they are 32 to 37 weeks of gestational age, have respiratory distress (RD) in the first 24 h of life, intubated and have invasive respiratory support using HFOV. Signs of RD are tachypnea (respiratory rate > 60/min), grunting, nasal flaring, chest retraction, and need of oxygen supplementation or other respiratory support.

Exclusion criteria

1. Known major congenital anomalies including congenital heart diseases.
2. Fetal hydrops.
3. Babies with congenital heart diseases

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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72 participants in 1 patient group

Lung recruitment

Experimental group

Description:

preterm infants with moderate to severe respiratory distress

Treatment:

Other: Lung recruitment