Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children

San Donato Group (GSD)

Status: Enrolling

Conditions: Pediatric Brain Tumor

Treatments: Diagnostic Test: 11C-MET-PET/RMN

Study type: Observational

Funder types: Other

Identifiers

NCT06226519

PET/RMN

Details and patient eligibility

About

Nuclear magnetic resonance imaging (NMR) is used in pediatric brain tumors for purposes of diagnosis, evaluation of response to treatments, and monitoring of patients in follow-up. Through conventional imaging techniques it remains difficult to differentiate tumor recurrence from pseudo-progression or other iatrogenic changes after radiotherapy or chemotherapy, but it remains a relevant and essential clinical need for patient management.

Enrollment: 60 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children and/or adolescents (≤18 years) diagnosed with brain tumor.
• children who underwent the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy.

Exclusion criteria

• patients >18 years