Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders (ROP)

University of Oslo

Status: Completed

Conditions: Substance Use Disorders; Mood Disorders; Anxiety Disorders

Treatments: Behavioral: Treatment as usual; Behavioral: Integrated mental health and substance use treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT00447733

78i068

NFR175394/V50 (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to determine whether Integrated Treatment is effective in the treatment of anxiety and/or depression with co-occurring substance use disorders.

Full description

Patients with mental disorders and co-occuring substance use disorders are characterized by high suicide rates, high treatment drop-out rates and long-lasting interpersonal, work, school, health and legal problems. Because mental disorders and substance use disorders co-exist and interact, it may be important to provide a treatment that addresses the substance misuse and mental health problems in an integrated and comprehensive way. Additionally, the health services for patients with mental health and substance use disorders are usually provided by different services and health professionals that rarely cooperate or have qualifications on both kinds of disorders. This also calls for an integration of the services on an organizational level. This approach of integrating services and treatment approaches for both diseases in a comprehensive way is called Integrated Treatment. Several studies have shown that Integrated Treatment is effective in treating the comorbidity of severe mental illness and substance use disorders. The over-all aim of this study is to evaluate the effects of evidence-based Integrated Treatment in anxiety and/or depression with co-occurring substance use disorders. The effects of the treatment will be assesses on changes in substance use and psychopathology.

Comparison: patients receiving treatment-as-usual or non-manualized treatment at general mental health outpatients clinics.

Enrollment: 76 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of substance use disorder
• clinical diagnosis of anxiety disorders
• clinical diagnosis of nonpsychotic mood disorders
• written consent
• planning to live in the catchment area during the treatment

Exclusion criteria

• schizophrenia spectrum disorders
• other psychotic disorders
• mental retardation
• nicotine abuse/dependency only
• prescription drug abuse/dependency only
• planning to move out of the catchment area during the study
• not able to read or write Norwegian

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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76 participants in 2 patient groups

Integrated treatment

Experimental group

Description:

Evidence-based psychosocial and pharmacological treatment of both the substance use disorder and the mental health disorder is provided at the same time and by the same therapists in a comprehensive way.

Treatment:

Behavioral: Integrated mental health and substance use treatment

Treatment as usual

Active Comparator group

Description:

Non-manualized clinic-based treatment provided by therapists without formal training in integrated treatment of co-occurring disorders.

Treatment:

Behavioral: Treatment as usual