Integrated Whole-Genome Analysis of Hematologic Disorders

Stanford University

Status: Completed

Conditions: Hematologic Diseases

Treatments: Procedure: Skin Biopsy; Procedure: Blood Draw

Study type: Observational

Funder types: Other

Identifiers

NCT01108159

HEM0013

1081737-100-DHAAT

16329 (Other Identifier)

SU-09092009-3820 (Other Identifier)

Details and patient eligibility

About

We will use new technologies to look at the DNA, RNA, proteins, and metabolites in the disease-containing blood, bone marrow, or tissue and normal cells from the skin. Our goal is to analyze all of the genes in the diseased and normal skin sample. By comparing the results of the diseased sample and normal skin cells and the results of the two types of genetic information (DNA and RNA), we should be able to identify genetic changes that are important for the initiation, progression, or treatment response of that particular disorder.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 years of age or older
2. Patient meets the clinical and/or pathologic criteria for the hematologic disorder being examined.
3. Patient is willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.

Exclusion criteria

1. Less than 18 years of age
2. Patient is not willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.