Integrating ESAGE with EHR Data Using Machine Learning for the Early Detection and Monitoring of Cognitive Impairment in Individuals

Douglas Scharre

Status: Invitation-only

Conditions: Alzheimer Disease; Mild Cognitive Impairment; Dementia; Worried Well

Treatments: Diagnostic Test: electronic self administered gerocognitive examination (eSAGE)

Study type: Observational

Funder types: Other

Identifiers

NCT06017505

2023H0249

Details and patient eligibility

About

The goal of this observational trial is to leverage the electronic Self-Administered Gerocognitive Examination (eSAGE), a variety of metadata (a set of data that describes and gives information about other data) collected during eSAGE testing, electronic health records (EHR) information, and advanced machine learning (ML) techniques to develop a new tool that can aid in early-stage prediction of individuals with cognitive impairments.

Full description

This is a retrospective and prospective record review trial for patients who are followed at the Center for Cognitive and Memory Disorders.

eSAGE assessment data (including cognitive data, behavioral data, timing data and other metadata) as well as varying amount of electronic health records (EHR) data will be collected on all eligible subjects. Machine learning techniques with feature selection will identify important EHR variables to determine what may be useful for the prediction of cognitive impairment.

Based on the EHR analysis additional questions will be added to the eSAGE to make an enhanced eSAGE version (eSAGE+). The goal of the eSAGE+ is to facilitate the identification of cognition impairment, and ultimately have a translational impact on Alzheimer's disease (AD) identification and management.

Enrollment: 1,486 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Males and females 50 years of age and over who complete the eSAGE as part of their office visit at the Center for Cognitive and Memory Disorders.

Exclusion criteria

• None

Trial design

1,486 participants in 1 patient group

Subject population

Description:

Males and females 50 years of age and over who complete the eSAGE as part of their office visit at the Center for Cognitive and Memory Disorders.

Treatment:

Diagnostic Test: electronic self administered gerocognitive examination (eSAGE)