Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer (ISC-LDCT)

Oulu University Hospital

Status: Enrolling

Conditions: Smoking Cessation

Treatments: Other: Written materials for smoking cessation; Other: Smartphone application; Other: low-dose computed tomography

Study type: Interventional

Funder types: Other

Identifiers

NCT07331519

EETMK 15/2025 (Other Identifier)

Details and patient eligibility

About

The study investigates effectiveness of different smoking cessation methods and low-dose CT based lung cancer screening

Full description

The study population consists of individuals aged 50-74 years with a significant smoking history who continue to smoke. The study design is a prospective and participants are randomized into three study arms: low-dose CT (LDCT) + smoking cessation with a smartphone application (arm 1), LDCT + smoking cessation with written materials (arm 2), smoking cessation with a smartphone application without LDCT (arm 3). The study compares effectiveness of smoking cessation methods, LDCT in lung cancer screening, lung cancer stage distribution, and lung cancer specific survival.

Enrollment: 1,200 estimated patients

Sex: All

Ages: 50 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Able to provide written informed consent
2. Age between 50-74
3. Smoked ≥ 15 cigarettes/day for ≥ 25 years or smoked ≥ 10 cigarettes/day for ≥ 30 years and are active smokers (smoking during the last two weeks)
4. Access to a smartphone (iPhone or Android)

Exclusion criteria

1. Current or past melanoma, lung, renal or breast cancer
2. A chest CT examination less than one year before inclusion
3. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial
4. No access to a smartphone (iPhone or Android)
5. Participant is unwilling or unable to comply with treatment and trial instructions
6. Any condition that study investigators consider an impediment to safe trial participation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,200 participants in 3 patient groups

Arm 1

Experimental group

Description:

Smoking cessation with a smartphone application + LDCT lung cancer screening

Treatment:

Other: low-dose computed tomography

Other: Smartphone application

Arm 2

Active Comparator group

Description:

Smoking cessation with written materials + LDCT lung cancer screening

Treatment:

Other: low-dose computed tomography

Other: Written materials for smoking cessation

Arm 3

Active Comparator group

Description:

Smoking cessation with a smartphone application without LDCT lung cancer screening

Treatment:

Other: Smartphone application