Integrative Analysis of CRC Liver Metastasis (CRC-LM)

Da Fu

Status: Enrolling

Conditions: Metastasis

Treatments: Other: normal colorectal tissues

Study type: Observational

Funder types: Other

Identifiers

NCT02917707

Y219J11311

Details and patient eligibility

About

The investigators will perform integrative analysis of CRC liver metastasis

Full description

The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≤ 75 years with histologically proven CRC
• No severe major organ dysfunction
• WHO performance status of 0 or 1
• No prior cancer chemotherapy

Exclusion criteria

• Age ≥ 76
• Severe major organ dysfunction
• World Health Organization (WHO) performance status of >1
• Prior cancer chemotherapy

Trial design

1,000 participants in 3 patient groups

normal colorectal tissues (PN)

Description:

normal colorectal tissues

Treatment:

Other: normal colorectal tissues

primary colorectal carcinoma tissues

Description:

primary colorectal carcinoma tissues

Treatment:

Other: normal colorectal tissues

liver metastasis tissues

Description:

liver metastasis tissues

Treatment:

Other: normal colorectal tissues