Integrative Chinese and Western Medicine for Knee Osteoarthritis

Chang Gung Medical Foundation

Status: Not yet enrolling

Conditions: Knee Osteoarthristis

Treatments: Drug: Western Medicine; Procedure: acupuncture; Procedure: herbal medicine and acupuncture; Drug: herbal medicine

Study type: Interventional

Funder types: Other

Identifiers

NCT07072442

NMRPG8Q6021

Details and patient eligibility

About

This study aims to investigate if an integrated approach combining Traditional Chinese and Western medicine can better treat knee osteoarthritis. The goal is to see if this combined therapy can more effectively reduce pain severity and frequency, leading to an improved quality of life for KOA patients. Additionally, the study will explore the underlying mechanisms of pain and anti-inflammation related to KOA.

Enrollment: 228 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female aged above 18 years old
• Kellgren-lawrence grading scale ≥ II
• Numerical rating scale (NRS) ≥ 4

Exclusion criteria

• History of bone tumor
• Pregnancy
• History of bilateral knee replacement
• Active infection

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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228 participants in 4 patient groups

Western medicine

Active Comparator group

Description:

Western medicine treatment only

Treatment:

Drug: Western Medicine

Herbal medicine and acupuncture

Experimental group

Description:

Western medicine combined herbal medicine and acupuncture

Treatment:

Procedure: herbal medicine and acupuncture

herbal medicine

Experimental group

Description:

Western medicine combined herbal medicine

Treatment:

Drug: herbal medicine

Acupuncture

Experimental group

Description:

western medicine combined acupuncture

Treatment:

Procedure: acupuncture