Integrative Omics Analysis for Colorectal Cancer and Metastasis

fan li

Status: Enrolling

Conditions: Colorectal Cancer

Treatments: Other: Integrative omics

Study type: Observational

Funder types: Other

Identifiers

NCT05482529

IOACCM

Details and patient eligibility

About

The pathogenesis of Colorectal cancer (CRC) metastasis remains unclear.We collect clinical data from our center and use Integrative omics to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.

Full description

Colorectal cancer (CRC), one of the most common malignant cancer around the world, CRC patients with distant metastasis. However, the pathogenesis of metastasis remains unclear. Integrative omics have begun to enable personalized medicine at an extraordinarily detailed molecular level. All patients with colorectal cancer and metastasis in our center who meet the inclusion criteria and exclusion criteria will be enrolled. The specimen collected by surgery and clinical data will be collected . We use Integrative omics such as RNA-sequencing,ATAC-seq(Assay for Transposase-Accessible Chromatin using sequencing), CUT&Tag（ Cleavage Under Targets and Tagmentation）to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis. This study will contribute to understanding the molecular mechanism of CRC metastasis in depth and contribute to the discovery of new appropriate molecular diagnostic and therapeutic targets, and more accurately prognose long term outcome in patients with CRC.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• colorectal adenocarcinoma by biopsy。
• at least 1 metastasis lesion comfirmed by at least 1 kind of imaging examination (CT, MRI and PET-CT )

Exclusion criteria

• recent diagnosis with other malignancies
• can not tolerate the surgery
• history of serious mental illness
• pregnancy or lactating women
• the researchers believe the patients should not enrolled in

Trial design

20 participants in 1 patient group

colorectal cancer with metastasis

Description:

colorectal cancer patients with at least one distant metastasis(liver, lung)

Treatment:

Other: Integrative omics