Integrative Personal Omics Profiling for Dynamic Molecular Phenotypes Monitoring During Fiber Supplementation
Status
Conditions
Treatments
Details and patient eligibility
About
The investigators propose a comprehensive, multiomic study that will integrate longitudinal data associating changes in specific gut bacteria and host in response to prebiotic fiber supplementation. These data will guide the development of an integrative biological signature relating bacterial-derived metabolites with biological outcome in the host.
Full description
With this study, the investigators propose to assemble a cohort of healthy individuals that will receive prebiotic supplementation, during comprehensive, longitudinal characterization of the microbiota and host changes with clinical markers and multiple omics assays. These multiomic data will then be integrated, generating unique biological signatures that define the role that microbial metabolites from specific bacteria play in host biological activity. Through this study the investigators expect to gain a detailed and clear understanding of the physiological changes, at the mechanistic level, that occur in the microbiome and host in response to dietary supplementation with prebiotic fiber.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Good general health
Exclusion criteria
- Fasting Blood Sugar >126 mg/dL
- Triglycerides >400 mg/dL
- Uncontrolled hypertension
- Vascular disease
- Chronic inflammatory conditions
- Major organ disease
- Heavy alcohol use
- Pregnancy/lactation
- Prior bariatric surgery
- Active psychiatric disease
- Use of medication known to affect carbohydrate or lipid metabolism
- Active eating disorder
Trial design
Primary purpose
Allocation
Interventional model
Masking
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal