Intensity-modulated Radiation Therapy Combined With Cisplatin or Nedaplatin Chemotherapy in Nasopharyngeal Carcinoma

Army Medical University of People's Liberation Army

Status and phase: Unknown; Phase 2

Conditions: Nasopharyngeal Carcinoma

Treatments: Drug: Nedaplatin; Drug: Cisplatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01265147

Daping H 001

Details and patient eligibility

About

This phase II trial is studying cisplatin or nedaplatin combine with IMRT to evaluate which one is better efficacy and security in nasopharyngeal carcinoma.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age≥18,T1-2aN1-3;T2-4NxNPC,VEGFR+,++,KPS>70,Life expectancy≥6 months, No uncontrolled hypertension,cardiac failure,diabetes,lunacy

Exclusion criteria

Distant metastasis, recurrent disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Cisplatin

Active Comparator group

Description:

cisplatin combine with IMRT

Treatment:

Drug: Cisplatin

Nedaplatin

Experimental group

Description:

Nedaplatin combine with IMRT

Treatment:

Drug: Nedaplatin