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Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer

Memorial Sloan Kettering Cancer Center (MSK) logo

Memorial Sloan Kettering Cancer Center (MSK)

Status and phase

Completed
Phase 2

Conditions

Thyroid Cancer

Treatments

Drug: Doxorubicin
Radiation: IMRT
Device: DWI MRI
Other: Modified Barium Swallow Impairment Profile (MBSImP)

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this Phase 2 study is to find out what effect, good and/or bad, external beam radiation therapy, has on the patient and their thyroid cancer where surgery is not an option or where despite surgery, the disease is still present.

Enrollment

27 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Pathologically confirmed diagnosis of non-anaplastic non-medullary thyroid cancer that is either grossly recurrent after surgery or unresectable with or without metastatic disease.
  • Age ≥18 years
  • Karnofsky performance status ≥70%
  • Men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months after treatment.
  • Patients must have ability to understand and the willingness to sign a written informed consent document.

Exclusion criteria

  • Women who are pregnant or lactating
  • Inability to comply with study and/or follow-up procedures

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

27 participants in 1 patient group

IMRT and doxorubicin
Experimental group
Description:
All patients will undergo radiation treatments using IMRT with concurrent low-dose radiosensitizing doxorubicin at 10 mg/m2 will be administered.
Treatment:
Device: DWI MRI
Other: Modified Barium Swallow Impairment Profile (MBSImP)
Radiation: IMRT
Drug: Doxorubicin

Trial documents
1

Trial contacts and locations

6

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Data sourced from clinicaltrials.gov

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