Intensity Modulated Radiotherapy in Recurrent T1-2 Nasopharyngeal Carcinoma

Fujian Provincial Cancer Hospital

Status: Completed

Conditions: Nasopharyngeal Cancer Recurrent

Treatments: Radiation: 3D-CRT, IMRT, BT, BT combined 3D-CRT or IMRT

Study type: Interventional

Funder types: Other

Identifiers

NCT02113423

FJCH009911

Details and patient eligibility

About

The hypothesis of the study is to address the efficacy and toxicity profile of aforementioned four modalities for rT1-2 NPC.

Characters of the patients:

• list item one: 168 patients, median age 48 years (range 16-75 years） proven rT1-2 NPC were diagnosed
• list item two: Treated with four different irradiation modalities(3D-CRT,IMRT, BT , BT Combined 3D-CRT or IMRT).
• list item three: Median time to recurrence was 30 months (range 1-180months). The median follow-up time was 28 months (range, 4-135 months).

Full description

Objectives:

Recurrent T1-2 Nasopharyngeal Carcinoma (rT1-2) may be salvaged by 3D - CRT（3D-Conformal Radiotherapy）, IMRT（ Intensity Modulated Radiotherapy）, Brachytherapy (BT), BT combined 3D - CRT or IMRT . The aim of this study is to address the efficacy and toxicity profile of aforementioned four modalities for rT1-2 NPC.

Methods and Materials:

168 patients, median age 48 years (range 16-75 years） proven rT1-2 NPC were diagnosed and treated with four different irradiation modalities(3D-CRT,IMRT, BT , BT Combined 3D-CRT or IMRT) . Median time to recurrence was 30 months (range 1-180months). The median follow-up time was 28 months (range, 4-135 months).

Enrollment: 168 patients

Sex: All

Ages: 16 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• recurrent T1-2 nasopharyngeal carcinoma patients

Exclusion criteria

• non recurrent T1-2 nasopharyngeal carcinoma patients

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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168 participants in 1 patient group

recurrent T1-2 NPC,no treatment

Experimental group

Description:

3D-CRT, IMRT, BT, BT combined 3D-CRT or IMRT

Treatment:

Radiation: 3D-CRT, IMRT, BT, BT combined 3D-CRT or IMRT