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Intensity Modulated Radiotherapy With Concomitant Boost in Breast Cancer

S

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status

Completed

Conditions

Breast Cancer
Radiation Toxicity

Treatments

Radiation: 3D-RT with sequential boost
Radiation: IMRT with concomitant boost

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

To assess feasibility of postoperative IMRT with concomitant boost in moderate-high risk breast cancer in terms of late toxicity and local control

Full description

Patients treated conservatively with moderate-high risk breast cancer were treated with IMRT plus concomitant boost to surgical bed (up to a dose of 50 Gy to whole breast and 60 Gy to the tumor bed).

Aim of the study was to evaluate late toxicity and local control after this treatment compared with a historical control group (CG) of patients treated with 3D-conformal postoperative radiotherapy delivered with conventional fractionation.

Enrollment

451 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

  • histologically confirmed invasive breast cancer (pT1-4) with at least one of these characteristics: 3 or more metastatic axillary nodes, pre or peri-menopausal status, close resection margins
  • breast conservative surgery

Exclusion criteria

  • positive margins
  • distant metastases

Trial design

451 participants in 2 patient groups

MARA-2: IMRT with concomitant boost
Description:
A forward planned IMRT technique was used and the prescribed dose to the whole breast was 50 Gy plus a concomitant boost of 10 Gy to the tumor bed
Treatment:
Radiation: IMRT with concomitant boost
CG: 3D-RT with sequential boost
Description:
The whole breast received 50.4 Gy in 28 fractions delivered with 3D-RT, followed by a sequential boost on the tumor bed of 10 Gy in 4 fractions delivered with electrons
Treatment:
Radiation: 3D-RT with sequential boost

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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