Intensive Arterial Pressure Control in Acute Coronary Syndrome (IAPREC)

University of Monastir

Status: Completed

Conditions: Acute Coronary Syndrome

Treatments: Drug: Isosorbide Dinitrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02135315

IAPREC

Details and patient eligibility

About

The intensive arterial pressure control in acute coronary syndrome (ACS) during the first 24 hours can improve the prognosis in the short and long term.

the study compare two treatment strategies (standard and intensive treatment) to assess their efficacy and safety in the treatment of acute coronary syndrome.

Full description

Acute coronary syndrome is often associated with arterial pressure elevation which are deleterious for the heart and needs urgent intervention to lower the blood pressure to the required values, however there is no clear recommendations concerning the treatment intensity in this situation.

The investigators know that high arterial pressure increases the oxygen myocardial consumption and it is deleterious in acute coronary syndrome, so , it is logical to reduce intensively this pressure.

Enrollment: 1,500 patients

Sex: All

Ages: 30 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non-ST segment elevation Acute Coronary Syndrome

Exclusion criteria

• SBP under 90 mmHg or hemodynamic instability
• Complicated ACS (arrythmias, atrio-ventricular block, shock, tamponade...) or ST elevation myocardial infarction (STEMI)
• Patients with contraindication to nitrates and/or beta blockers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

1,500 participants in 2 patient groups

intensive controle group

Experimental group

Description:

The end point in this group was to maintain the systolic blood pressure (SBP) between 110 and 120 mmHg using continuous intravenous Isosorbide Dinitrate perfusion, and Labetalol if needed.

Treatment:

Drug: Isosorbide Dinitrate

standard control group

Active Comparator group

Description:

The end point in these group was to maintain the systolic blood pressure under 140 mmHg using continuous intravenous Isosorbide Dinitrate perfusion, and Labetalol if needed.

Treatment:

Drug: Isosorbide Dinitrate