Intensive Control of Blood Pressure in Acute Ischemic Stroke After Endovascular Therapy on Clinical Outcome (CRISIS I)

Nanjing Medical University

Status

Terminated

Conditions

Acute Ischemic Stroke

Treatments

Other: Intensive BP lowering

Study type

Interventional

Funder types

Other

Identifiers

NCT04775147

CRISIS I

Details and patient eligibility

About

CRISIS I is a prospective, multicenter, randomized controlled trial, to asses the impact of intensive blood pressure control on clinical outcome of acute ischemic stroke patients with successful recanalization after endovascular therapy.

Full description

CRISIS I aims to determine the effectiveness of more intensive BP lowering target (<120 mmHg) compared to standard BP management target (<140mmHg) on functional outcome in patients with successful recanalization post-MT for AIS due to anterior circulation large vessel occlusion (LVO).

Enrollment

205 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years
Diagnosis of AIS with anterior circulation LVO confirmed by brain imaging
To receive MT <24 hours after AIS onset according to local guidelines
Successful recanalization (TICI score ≥2b) after MT
Sustained systolic BP ≥140 mmHg (defined as 2 successive readings <10 mins) within 60 minutes after recanalization
Provide written informed consent (or approved surrogate)
Perform CTA or MRI before endovascular therapy
Signed an approved informed consents

Exclusion criteria

Significant pre-stroke disability (mRS scores 2-5)
Definite indication/contraindication to different intensities of BP lowering treatment
Specific contraindications to any of the BP agents to be used (eg, patients who are hypersensitive (allergic) to any of the ingredients)
Unlikely to potentially benefit from therapy (e.g. advanced dementia) or very high likelihood of death within 24 hours post-MT, judged by responsible treating clinician
Other medical illness that interferes with outcome assessments and follow-up (e.g.advance cancer and renal failure); Women who are lactating
Other conditions inappropriate for inclusion judged by investigators