Interaction of Apelin and Angiotensin in the Systemic Circulation

University of Edinburgh

Status: Completed

Conditions: Renin Angiotensin System

Treatments: Drug: Saline; Drug: Angiotensin II

Study type: Interventional

Funder types: Other

Identifiers

NCT01049646

FS/09/019/26905 - 2

Details and patient eligibility

About

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.

Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.

Enrollment: 12 estimated patients

Sex: Male

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• > 18 years old
• Healthy volunteers

Exclusion criteria

• Lack of informed consent
• Age < 18 years,
• Current involvement in other research studies,
• Systolic blood pressure >190 mmHg or <100 mmHg
• Malignant arrhythmias
• Renal or hepatic failure
• Haemodynamically significant aortic stenosis
• Severe or significant co morbidity
• Women of childbearing potential.

Any regular medication

• Previous history of any cardiovascular disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Angiotensin II

Active Comparator group

Treatment:

Drug: Angiotensin II

Saline infusion

Placebo Comparator group

Treatment:

Drug: Saline