Interaction of Muscle Dystrophy, Glucose Metabolism and Insulin Sensitivity (MyoMet)

Charité University Medicine Berlin

Status

Unknown

Conditions

Various Forms of Skeletal Muscle Dystrophy

Treatments

Diagnostic Test: oral glucose load at rest

Diagnostic Test: oral glucose load and exercise

Study type

Observational

Funder types

Other

Identifiers

NCT05052073

MyoMet

Details and patient eligibility

About

The aim of this project to characterize systemic and organ-specific (subcutaneous adipose tissue and skeletal muscle) metabolic responses at rest and during standardized, moderate exercise after an oral glucose load in patients with various geneticaly heritable foms of skeletal muscle dystrophies. Metabolic responses will be monitored by indirect calorimetry (canopy and/or metabolic chamber at rest and during exercise) and microdialysis (adipose tissue and skeletal muscle at rest) before and after an oral glucose load (75 g).

Enrollment

60 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

controls: healthy, no metabolic, endocrine, neurologic or other diseases
patients: genetically confirmed diagnosis of muscle dystrophy

Exclusion criteria

known hemorrhagic diseases / coagulopathies
intake of oral anti-coagulant drugs (control of PTT, INR and platelet count before study entry)
insulin-dependent Diabetes mellitus
pregnancy and lactation period
chronic use of non-steroidal antiphlogistics
alcohol and drug abuse
Claustrophobia • gleichzeitige Teilnahme an einer anderen Studie; Teilnahme an einer Studie vor weniger als zwei Monaten Unfähigkeit, die mündlichen und schriftlichen Informationen zur Studie zu verstehen und das schriftliche Einverständnis zu geben