Interaction of Otolith Stimulation and Carotid Baroreflex in Humans (OTOBAR)

Caen University Hospital

Status

Unknown

Conditions

Healthy Volunteers

Treatments

Procedure: Stimulation of the carotid baroreceptors with a pressure system

Study type

Interventional

Funder types

Other

Identifiers

NCT02565095

08-128

Details and patient eligibility

About

It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning.

The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.

Enrollment

54 estimated patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers, male and / or female aged 18-30 years
subject affiliated to a social security scheme, agreeing to participate in the study and who provided informed consent.

Exclusion criteria

who participated in a clinical trial within less than the period of exclusion from this project
with a past or present history of heart disease, vascular, neurological, respiratory, rheumatological, metabolic or otologic.
pregnant women (dosage beta HCG)
having taken any medication heart, vascular, neurological, respiratory, rheumatological, metabolic or might interfere on vestibular test results during the two years preceding the experiment.
smoking or smoking more than 5 cigarettes / day, 1 cigarette / day or 1 pipe / day