Interaction of Potassium and Genetic Risk Variants on Diabetes Risk

Duke University

Status: Completed

Conditions: Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT03367455

Pro00065581

Details and patient eligibility

About

The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.

Enrollment: 11,812 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts

Exclusion criteria

• Had not fasted 8 or more hours for the baseline visit
• Prevalent diabetes at baseline exam
• Missing information on serum potassium
• Missing single nucleotide polymorphism (SNP) data
• Evidence of kidney dysfunction
• Race other than black/African American or white/Caucasian
• Missing other covariates

Trial design

11,812 participants in 1 patient group

ARIC and JHS participants

Description:

A combined cohort of Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) participants