Interaction of Salivary Proteins and Polyphenols

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Purdue University

Status

Completed

Conditions

Diet Habit
Taste, Altered
Diet Modification
Saliva Altered

Treatments

Other: Chocolate milk substitute with gelatin
Other: Chocolate milk substitute
Other: Chocolate Milk

Study type

Interventional

Funder types

Other

Identifiers

NCT03501238
082-002

Details and patient eligibility

About

Participants will be chosen through an initial sensory test to find high and low-perceivers of astringency. Selected participants will drink a chocolate milk or milk substitute beverage for one week each with washout weeks in between. At the end of each week participants will taste and rate multiple beverages for their astringency and other sensory properties. Participants will provide saliva samples weekly for proteomic analysis and (potentially) analysis of polyphenols. Participants will also be asked to provide a 24 hour dietary recall once per week. Data will be analyzed to determine if there is a relationship between polyphenol exposure, astringency ratings, and salivary protein composition.

Enrollment

63 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • High or low perceivers of astringency (from initial screening)

Exclusion criteria

  • Current smokers (within 30 days), dairy/nut/cocoa allergies, piercings in mouth, mid-range perceiver of astringency, issues with taste, smell, swallowing or choking.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

63 participants in 6 patient groups

BSG
Experimental group
Description:
Participant receives bovine milk, then milk substitute, then milk substitute treated with gelatin
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin
BGS
Experimental group
Description:
Participant receives bovine milk, then milk substitute with gelatin, then milk substitute
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin
SBG
Experimental group
Description:
Participant receives milk substitute, then bovine milk, then milk substitute with gelatin.
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin
SGB
Experimental group
Description:
Participant receives milk substitute, then milk substitute with gelatin, then bovine milk
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin
GSB
Experimental group
Description:
Participant receives milk substitute with gelatin, then milk substitute, then bovine milk.
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin
GBS
Experimental group
Description:
Participant receives milk substitute with gelatin, then bovine milk, then milk substitute.
Treatment:
Other: Chocolate Milk
Other: Chocolate milk substitute
Other: Chocolate milk substitute with gelatin

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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