Interaction of Statins and Nondepolarizing Muscle Relaxants

Huang-wei LV

Status: Unknown

Conditions: Pain

Treatments: Drug: Rocuronium

Study type: Observational

Funder types: Other

Identifiers

NCT02222519

2014071801

Details and patient eligibility

About

provide evidence for prevention or reduction muscle pain.

Full description

The purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,In order to provide evidence for prevention or reduction muscle pain.

Enrollment: 60 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with American Society of Anesthesiologists physical status I-III
• Patients taking statins for at least 3 months and those who had never used statins were considered to be eligible

Exclusion criteria

• Orthopedic
• Spinal surgery
• Surgery involving extensive muscle manipulation
• History of liver and kidney failure
• Neuromuscular disease
• Susceptibility to or family history of malignant hyperthermia
• Extensive denervation of skeletal muscle
• Chronic pain syndromes
• Taking medications that might interact with the effect of rocuronium or serum myoglobin difficult intubation

Trial design

60 participants in 2 patient groups

Statin use group

Description:

patients taking statins for at least 3 months

Treatment:

Drug: Rocuronium

non statin use

Description:

no history of taking statin

Treatment:

Drug: Rocuronium