Interactions Between Drug Effects and Environments II

University of Illinois

Status and phase: Completed; Phase 4

Conditions: Substance-Related Disorders

Treatments: Behavioral: Paired; Drug: Placebo; Drug: Stimulant or sedative

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03075501

R21DA033488-01A1 (U.S. NIH Grant/Contract)

2015-0075

Details and patient eligibility

About

The purpose of the study is to determine how associations between drugs and the places where they are experienced influence drug seeking, mood and acute drug responses.

Full description

Learned associations between drug effects and the people, places, and paraphernalia (cues) linked with drug experiences are a major barrier to the treatment of drug addiction. These links are remarkably persistent and can cause relapse to drug taking even after long periods of abstinence. They are also key features in some of the foremost theories of addiction, yet there is little clinical evidence of how these associations are formed and how they come to profoundly control behavior. The long-term goal of this research is to understand how drug cues become powerfully linked with drug experiences and their influence on mood and behavior. In the proposed project, the investigators will use a de novo conditioning paradigm to examine the influence of drug contexts on drug seeking, mood and acute drug responses. The hypothesis is that drug-paired contexts gain motivational salience, induce approach, and alter acute subjective responses to the drug.This knowledge will lead to novel treatment strategies to counteract the effects of drug cues on mood and behavior, and also to prevent relapse.

Enrollment: 133 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• past use of stimulants
• bmi 19-26
• hormonal birth control for women

Exclusion criteria

• current or recent (Past year) history of major axis I disorder

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

133 participants in 2 patient groups

Paired

Active Comparator group

Description:

Individuals receive drug (stimulant, or sedative) on two separate occasions and placebo on two separate occasions. Individuals receive drug in only one room.

Treatment:

Drug: Placebo

Drug: Stimulant or sedative

Behavioral: Paired

Unpaired

Other group

Description:

Individuals receive drug (stimulant, or sedative) on two separate occasions and placebo on two separate occasions. Individuals receive drug in both rooms.

Treatment:

Drug: Placebo

Drug: Stimulant or sedative