Interactions Between Fibre and Polyphenols on Colonic Phenolic Acid Production and Biomarkers of Health ( 6 Weeks)

University of Glasgow

Status: Completed

Conditions: Healthy

Treatments: Other: TOL soup with inulin; Other: Tomato, onion and lovage soup (TOL)

Study type: Interventional

Funder types: Other

Identifiers

NCT03840746

BB/M027724/1-3

Details and patient eligibility

About

The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage & onions, with and without inulin. The investigators now wish to study the longer-term interactions of these foods over 6 weeks as well as their impact on biomarkers of human health, the gut microbiome, human proteome and markers of risk of chronic disease. This may allow better targeted evaluation of foods which influence health through the gut microbiome.

Full description

Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols.

Colonic bacteria are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as inulin to short chain fatty acids. It is likely that there are key interactions in the colonic bacterial metabolism of NDC and phenolics. The investigators hypothesize that combination of polyphenolics (in onions, tomatoes and lovage) with inulin (NDC) will increase the urinary output of bioactive phenolic acids over a 6 week feeding trial and impact on biomarkers of cardiometabolic health.

Enrollment: 90 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Generally healthy
• BMI>=25
• Not on antibiotics within 3 months of starting of study
• No medication likely to influence gut function, colonic bacterial activity.

Exclusion criteria

• Antibiotics
• Pregnancy
• lactation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

Habitual diet

No Intervention group

Description:

participants remain on their habitual diet

Tomato, onion and lovage soup (TOL)

Experimental group

Description:

One tin of soup containing Tomato onion and lovage daily for 6 weeks

Treatment:

Other: Tomato, onion and lovage soup (TOL)

TOL soup with inulin

Experimental group

Description:

One tin of Tomato, onion and lovage soup with added inulin for 6 weeks

Treatment:

Other: TOL soup with inulin