Interactions of Brain Regions in Visuomotor Adaptation

University of Virginia

Status: Unknown

Conditions: High Intensity Focused Ultrasound; Deep Brain Stimulation

Treatments: Behavioral: Behavioral Assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT04190940

21483

Details and patient eligibility

About

The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance "on" and "off" thalamic electrical stimulation.

Enrollment: 39 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor
• Able to provide informed consent and complete study procedures
• Must speak English
• Age 18-85

Exclusion criteria

• Not receiving one of the specified inclusion criteria
• Unable to provide consent or complete study procedures
• Women who self-report pregnancy
• Patients who are currently incarcerated

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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39 participants in 2 patient groups

High Intensity Focused Ultrasound

Experimental group

Description:

Patients receiving high intensity focused ultrasound as a treatment will be asked to complete the behavioral task pre and post their treatment.

Treatment:

Behavioral: Behavioral Assessment

Deep Brain Stimulation

Experimental group

Description:

Patients receiving deep brain stimulation as a treatment will be asked to complete the behavioral task while their DBS electrode is "on" and "off".

Treatment:

Behavioral: Behavioral Assessment