Interchromosomal Insertion Carriers PGT-SR

University Hospital Center (CHU)

Status: Completed

Conditions: Infertility; Interchromosomal Breakpoint

Study type: Observational

Funder types: Other

Identifiers

NCT04978402

RECHMPL21_0486

Details and patient eligibility

About

Interchromosomal insertions (IT) are rare and complex structural rearrangements. Theoretically, the risk to have a child to term with a malformation or mental retardation can reach 50% related to the proportion of unbalanced gametes produced from behavior of chromosomes during meiosis. However, the meiotic segregation of IT has rarely been studied. This study provide an accurate reproductive risk of IT carriers resulting from a combined analysis of Sperm-FISH and preimplantation genetic testing for structural rearrangement (PGT-SR) management of IT carriers.

Enrollment: 3 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient whom carrying Insertional translocation in the context of PGT-SR management

Exclusion criteria

• Patient who reject the study protocol