Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio in IgA Nephropathy (LYMFONI)

Centre Hospitalier Universitaire de Besancon

Status: Enrolling

Conditions: Glomerulonephritis, IGA

Treatments: Other: Blood collection; Other: Urine sample

Study type: Interventional

Funder types: Other

Identifiers

NCT05791162

2023/748

Details and patient eligibility

About

This study aims to investigate the relevance of the Tfh/Tfr (Follicular helper T cells/ Follicular regulatory T cells) ratio in patients with IgA nephropathy:

• To identify a differential expression of the Tfh/Tfr ratio in patients considered stable or progressive
• To predict, at diagnosis, the clinical evolution of the disease (progressive or stable form) in the first year.

Enrollment: 75 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IgA nephropathy histologically proven on renal biopsy according to KDIGO criteria, with 8 permeable glomeruli (patients diagnosed from 2009 with a minimum follow-up for their nephropathy of 5 years (arm 1) or patients diagnosed during the study (arm 2))

Control patients: Lupus or ANCA-associated vasculitis or polycystic kidney disease (arm 3)

Exclusion criteria

• Legal incapacity or limited legal capacity
• Subjects with no social security coverage.
• Pregnancy / No effective contraceptive method

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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75 participants in 3 patient groups

IgA nephropathy in follow-up (arm 1)

Other group

Description:

Diagnosis of IgA nephropathy from 2009, with a minimum follow-up for nephropathy of 5 years

Treatment:

Other: Urine sample

Other: Blood collection

Newly diagnosed IgA nephropathy (arm 2)

Other group

Description:

Diagnosis of IgA nephropathy during the study period

Treatment:

Other: Urine sample

Other: Blood collection

CD163s control (arm 3)

Other group

Description:

Diagnosis of Lupus or ANCA-associated vasculitis or polycystic kidney disease

Treatment:

Other: Urine sample