Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis (Endophtalmitis)

University Hospital Center (CHU) Dijon Bourgogne

Status and phase: Completed; Phase 3

Conditions: Post-operative Endophthalmitis

Treatments: Procedure: Intravitreal injection of antibiotics; Procedure: Intravitreal injection of Betamethasone + antibiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT01768078

Creuzot-Garcher PHRC IR 2007

Details and patient eligibility

About

One useful effect of early intravitreal corticotherapy is to diminish inflammatory complications after endophthalmitis, which may cause, at least in part, serious complications (retinal detachment, macular edema) which are, more than the infection, causes of the complications seen after acute endophthalmitis.

Enrollment: 112 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients male or female with no age limit
• Hospitalized for the diagnosis and treatment of acute endophthalmitis following cataract surgery
• Who had given their consent after being informed about intravitreal corticotherapy

Exclusion criteria

• Patients who refused or were unable to give their consent
• Prior intravitreal corticotherapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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112 participants in 2 patient groups

with corticoids

Experimental group

Treatment:

Procedure: Intravitreal injection of Betamethasone + antibiotics

without corticoids

Other group

Treatment:

Procedure: Intravitreal injection of antibiotics