Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease (HORTIM)

Fondation Ophtalmologique Adolphe de Rothschild

Status

Terminated

Conditions

Horton Disease

Treatments

Radiation: Vascular tomodensitometry

Other: Magnetic resonance angiography

Other: Retinal angiography

Other: Retinal optical coherence tomography

Other: Vascular ultrasonography

Study type

Observational

Funder types

NETWORK

Identifiers

NCT02473029

GEL_2014_01

Details and patient eligibility

About

The study aims at measuring the sensitivity and specificity of a series of imaging signs (recorded by magnetic resonance angiography, vascular tomodensitometry, vascular ultrasonography, retina angiography and retina optic coherence tomography) for the diagnosis of Horton disease, the gold standard being the result of temporal artery biopsy.

Enrollment

45 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2 major criteria and at least one minor criteria.

Major criteria : Age > 50 ans ; headache ; intermittent jaw or tongue pain ; visual impairment ; ESR > 50 mm at 1h and/or CRP > 8mg/l.

Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever >38°C, weight loss >10%, anorexia, fatigue.

Exclusion criteria

Autoimmune disease
Active infectious condition
Malignant disease
Condition counterindicating one or several of the protocol's imaging procedures : allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic foreign body...