Interest of Molecular Analysis of Cerebral Thrombi in Determining the Prognosis and Etiology of Cerebral Infarction (MATISSE)

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Enrolling

Conditions: Ischemic Stroke

Treatments: Other: Thrombi and blood analyses

Study type: Observational

Funder types: Other

Identifiers

NCT05658835

ID-RCB (Other Identifier)

RCAPHM22_0231

Details and patient eligibility

About

The MATISSE (Molecular Analysis of Thrombus for Ischemic Stroke prognosis and Etiology) project evaluates the hypothesis that the molecular composition of cerebral thrombus in metabolites, lipids, and proteins conditions the clinical prognosis at 3 months of the infarction and informs on its etiological subtype

Enrollment: 311 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female 18 years of age or older;
• Patient with a cerebral infarction documented by brain imaging who received endovascular treatment by mechanical thrombectomy;
• Patient for whom it was possible to collect cerebral thrombus for LC-MS analysis during mechanical thrombectomy:
• Patient who was informed of the study and formulated a non-opposition to participation. If not, patient for whom a relative was informed and formulated a non-opposition.

Exclusion criteria

• Patient with a cerebral infarction documented by cerebral imaging, having benefited from an endovascular treatment with mechanical thrombectomy that did not allow the extraction of a cerebral thrombus.
• Protected persons (articles L1121-5, L1121-6 and L121-8 of the Public Health Code): pregnant or breast-feeding women, persons deprived of liberty, under guardianship or curatorship

Trial design

311 participants in 1 patient group

Patient suffering from ischemic stroke

Treatment:

Other: Thrombi and blood analyses