Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers

Toulouse University Hospital

Status: Completed

Conditions: Squamous Cell Carcinoma of Larynx; Squamous Cell Carcinoma of Oropharynx; Squamous Cell Carcinoma of Hypopharynx

Treatments: Procedure: WL and NBI

Study type: Interventional

Funder types: Other

Identifiers

NCT02035735

13 203 02

Details and patient eligibility

About

The aim of this study is to prospectively determine if the use of NBI endoscopy modifies the superficial extension of these tumors.

Full description

Several studies have already showed the interest of the use of NBI for the early diagnosis of malignancies of the upper aerodigestive tract. For all tumors, the most accurate evaluation of its limits is very important to perform the best strategy of treatment. If surgery seems to be the best option, surgical margins must be widely healthy. Despite the systematic transnasal flexible endoscopy with white lamp followed by laryngoscopy under general anesthesia (LGA) and tomodensitometric evaluation, surgical margins can be unhealthy (in situ carcinoma or dysplasia). We propose to evaluate if the use of the NBI could be useful to determine the superficial spread of squamous cell carcinomas in these locations.

To April 2013 to Mars 2015, all patients with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx and whom a LGA are expected, are included. The day before the LGA, two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light and the second one with NBI. All results are noted on a schema. Superficial extension or synchronous lesions showed by NBI are analysed and compared with with lamp technic.

After surgery, surgical margins were evaluated and healthy margins were measured.

Enrollment: 93 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who can benefit a laryngoscopic exam under general anesthesia

Exclusion criteria

• General anesthesia contra-indications
• Local anesthesia allergy
• Breast-feeding period or pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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93 participants in 1 patient group

Videoendoscopy with WL and NBI

Experimental group

Description:

The day before the laryngoscopy under general anesthesia (LGA), two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light (WL) and the second one with NBI (NBI).

Treatment:

Procedure: WL and NBI