Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis (VOPRABIO)

Centre Hospitalier Universitaire, Amiens

Status: Withdrawn

Conditions: Aortic Stenosis; Pulse Wave

Treatments: Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction; Other: Control group without heart disease

Study type: Interventional

Funder types: Other

Identifiers

NCT03140735

PI2016_843_0035

Details and patient eligibility

About

Aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. The purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. If this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age, without legal protection (guardianship or curatorship),
• Stable hemodynamic status.
• Affiliation to a social security scheme

Exclusion criteria

• Hemodynamically unstable patients: Systolic PA <10 cmHg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma
• History of significant valvulopathy other than an aortic stenosis,
• Pregnancy.
• Patient under tutelage or curatelle or deprived of public right.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 4 patient groups

Control group of 150 heart disease-free individuals

Other group

Treatment:

Other: Control group without heart disease

Patients with aortic sclerosis

Other group

Treatment:

Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction

Patients with moderate aortic stenting (RA)

Other group

Treatment:

Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction

Patients with Serious Aortic Retention

Other group

Treatment:

Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction