Interest of ß 1-3 D Glucan Assays in Screening for the Onset of Invasive Aspergillosis in Neutropenic Patients With Acute Leukaemia. (BETA GLUCAN)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Invasive Fungal Infections

Treatments: Biological: blood samples

Study type: Interventional

Funder types: Other

Identifiers

NCT02851680

DALLE 2013

Details and patient eligibility

About

In the context of screening for infectious fungal diseases in patients with malignant haemopathy, and particularly patients with acute leukaemia, the investigator aims to evaluate the performance of an already commercialized but little used serum screening test (Fungitell® test) and to determine its place in the management strategy for invasive aspergillosis.

Enrollment: 476 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have been informed about the study
• Patients over 18 years
• patients with acute myeloblastic leukaemia (AML) or lymphoblastic leukaemia (ALL) who have undergone cytotoxic chemotherapy with curative intent

Exclusion criteria

• Adults under guardianship
• Patients without national health insurance cover
• Pregnant or breast-feeding women
• allografts and autografts of Haematopoietic Stem Cells (HSC)

Trial design

476 participants in 2 patient groups

Fongitell test

Experimental group

Treatment:

Biological: blood samples

serum galactomannan

Active Comparator group

Treatment:

Biological: blood samples