Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury

Civil Hospices of Lyon

Status

Completed

Conditions

Cirrhosis

Diastolic Function

Acute Kidney Injury

Hepatorenal Syndrome

Treatments

Procedure: Echocardiography

Study type

Interventional

Funder types

Other

Identifiers

NCT02097784

2013.831

2013-A01622-43 (Other Identifier)

Details and patient eligibility

About

This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. Patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.

Enrollment

28 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients > 18 years
written consent for the participation of the study
cirrhosis with portal hypertension and ascite
acute kidney injury according to AKIN criteria (rapid increase of creatinine (48 hours) > 26.4 µmol or > 50% comparing with baseline). Baseline creatinine is the last value of creatinine before admission or creatinine at the admission if stable during 5 days.
absence of argument for acute tubular necrosis or other organic acute renal injury
absence of argument for shock

Exclusion criteria