Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas (APACH1)

Centre Francois Baclesse

Status and phase

Completed

Phase 2

Conditions

Hyperparathyroidism

Treatments

Radiation: F18-choline PET examination

Study type

Interventional

Funder types

Other

Identifiers

NCT02432599

APACH1

Details and patient eligibility

About

The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI (Tc-99m sestamibi) and cervical ultrasound, in order to avoid unnecessary bilateral cervical exploration.

Enrollment

28 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient aged 18 years or more;
Patient with a primary hyperparathyroidism and witj a negative or non-contriburatory MIBI parathyroid scintigraphy and neck ultrasonography, for which surgical resection is planned;
Confirmation of the diagnosis of primary hyperparathyroidism on laboratory tests
Affiliate to a social security system;
Patient written informed consent.

Exclusion criteria

Patient deprived of liberty, under guardianship;
Any medical or psychological condition witch could compromise the capacity of the patient to participate in the study;
Pregnant or breastfeeding