Interest of the Induction With Target-controlled Inhalation of Sevoflurane on Spikes Wave Occurrence (SIZE)

University Hospital of Bordeaux

Status: Completed

Conditions: General Anesthesia

Treatments: Drug: Induction with Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00775879

CHUBX 2004/01

Details and patient eligibility

About

Sevoflurane is widely used for induction of anaesthesia. Several studies showed EEG abnormalities during mask induction with sevoflurane. The aim of our study was to test the induction target concentration of sevoflurane on the spikes wave occurrence.

Enrollment: 34 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• programmed gynecological surgery
• ASA 1 or 2

Exclusion criteria

• arterial hypertension
• gastro-oesophageal reflux
• pregnancy
• diabetes
• obesity
• asthma
• tobacco

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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34 participants in 2 patient groups

A

Experimental group

Description:

2.5% target concentration

Treatment:

Drug: Induction with Sevoflurane

B

Active Comparator group

Description:

2.5% manually selected

Treatment:

Drug: Induction with Sevoflurane