Interference by Activated Protein C Resistance in the Determination of Protein S Activity (PS)

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Resistance to Activated Protein C in the Determination of Protein S Activity

Study type: Observational

Funder types: Other

Identifiers

NCT06182501

8674

Details and patient eligibility

About

Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Enrollment: 9,470 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient of legal age (≥ 18 years)
• Patient for whom a sample has been sent to the HUS Hematology Laboratory for measurement of protein S activity between 28/12/2009 and 29/12/2020
• Patient who does not object to the reuse of his/her medical data for scientific research purposes.

Exclusion criteria

• Minor patient
• Patient with incomplete data