Interindividual Variation in Excretion of Curcumin

University of Massachusetts, Amherst

Status: Completed

Conditions: Gut Microbiota; Metabolites

Treatments: Dietary Supplement: curcumin

Study type: Interventional

Funder types: Other

Identifiers

NCT03746158

2018-4937

Details and patient eligibility

About

The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.

Enrollment: 8 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-30 year old healthy adults

Exclusion criteria

• Exclusion criteria included those who are <18 or >30 years old, have a BMI of <20 or >29 kg/m2, have a weight change >4.5 kg in the past 3 months, exceed exercise activities of a curcumin level over the past 3 months, have any diseases, especially intestinal disorders, had abnormal liver or kidney function tests. Those who smoke, consume more than two alcoholic drinks per day, use medication affecting gut microbiota profile (e.g., antibiotics and probiotics) in past three months will also be excluded.
• Additionally, this study excludes menopausal women, those using hormone-based contraceptives, those with abnormal menstrual cycles, and those who are pregnant, lactating or planning to become pregnant.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Curcumin

Experimental group

Description:

subjects will be assigned to consume one capsule of curcumin (330 mg of curcumin per capsule) three times a day (one capsule with each meal).

Treatment:

Dietary Supplement: curcumin