Interleukin 38 as a Biomarker for Metabolic Syndrome in Psoriatic Patients

Sohag University

Status: Unknown

Conditions: Psoriasis

Treatments: Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit

Study type: Observational

Funder types: Other

Identifiers

NCT05076812

Soh-Med-21-09-02

Details and patient eligibility

About

case control study to compare level of interleukin 38 in patients with psoriasis and patients with metabolic syndrome with healthy control subjects

Full description

this case control study will measure plasma level of interleukin 38 in 4 groups of 24 subject, group one will have psoriatic patients, group 2 will have psoriatic patients with metabolic syndrome, group three will have patients with metabolic syndrome only, and group 4 will have healthy control subjects.

Enrollment: 96 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• specific to each group

Exclusion criteria

• Patient refusal. Age <18 years Pregnancy Lactation smoking Infections. Patients with other inflammatory skin disorders use of antioxidant and anti-inflammatory drugs patients on treatment for psoriasis

Trial design

96 participants in 4 patient groups

Group 1 (Psoriasis only)

Description:

contains 24 psoriatic patients, Psoriasis Area Severity Index will be measured, also waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile and finally: plasma level of interleukin 38

Treatment:

Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit

Group 2 (Psoriasis and metabolic syndrome)

Description:

contains 24 psoriatic patients with metabolic syndrome. Psoriasis Area Severity Index will be measured metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38

Treatment:

Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit

Group 3 (Metabolic syndrome only)

Description:

contains 24 patients with metabolic syndrome only. full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38

Treatment:

Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit

Group 4 (Healthy Controls)

Description:

contains 24 healthy control subjects full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is excluded after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38

Treatment:

Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit