Interleukin 4 and Interferon Gamma Predictors of Human Papillomavirus Immunotherapy in Warts

Zagazig University

Status: Completed

Conditions: Wart, Genital; Warts Hand

Treatments: Biological: IL-4 and IFN-γ measurements

Study type: Observational

Funder types: Other

Identifiers

NCT05100043

3140-23-10-2019

Details and patient eligibility

About

In the present study the investigators assessed the invitro role of IL-4 and IFN-γ in predicting the response to bivalent HPV vaccine after whole blood stimulation

Full description

40 Patients and 40 controls are enrolled in the study. Participants suffer from chronic recurrent cutaneous and genital warts. Blood samples were withdrawn then whole blood cultures are prepared. Cultures are stimulated with bivalent HPVvaccine. IL-4 and IFN-γ measurement in culture supernatants by ELISA. IL-4 and IFN-γ are investigated to predict the therapeutic response to bivalent HPV vaccine immunotherapy in warts.

Enrollment: 80 patients

Sex: All

Ages: 36+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with recurrent and recalcitrant cutaneous and anogenital warts.

Exclusion criteria

• History of allergy to the HPV vaccine
• Active viral, fungal, or bacterial infections
• Immunosuppressive diseases or drugs.
• Autoimmune diseases, or other systemic diseases, e.g., hepatic, or renal disorders, diabetes, meningitis or convulsions
• Skin allergies
• Pregnancy and lactation
• Earlier wart treatment at least one month before enrollment.

Trial design

80 participants in 2 patient groups

Cases

Description:

Patients having multiple recurrent and recalcitrant cutaneous and genital warts

Treatment:

Biological: IL-4 and IFN-γ measurements

Controls

Description:

Healthy volunteers matched for age and sex

Treatment:

Biological: IL-4 and IFN-γ measurements