Intermittent Hypoxia Intervention in MS Patients (MSHYPE)

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Multiple Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT04635033

MS HYPE Pilot

Details and patient eligibility

About

This observational cohort study investigates the safety and feasibility of an intermittent hypoxia intervention in multiple sclerosis.

Enrollment: 12 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-60 years
• confirmed MS (all types of MS)
• ability to come to the outpatient clinic 2-3x/week for 3 months
• EDSS ≤ 6.5
• inconspicuous medical examination
• inconspicuous ECG

Exclusion criteria

• relapse in the last 3 months
• EDSS progression in the last 6 months
• pregnancy
• contraindication for MRI
• severe heart disease
• severe asthma, COPD
• cancer
• severe cognitive deficits
• chronic headache
• renal insufficiency
• anaemia (Hb < 10 g/dl)
• insulin-dependent diabetes mellitus
• severe vascular stenosis
• former episodes of severe high mountain sickness
• cancer

Trial design

12 participants in 1 patient group

Intervention

Description:

2 hours of reduced FiO2 (11-15%) in the inspired air, 2-3x/week, 3 months