International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX)

Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

Status: Completed

Conditions: Colon Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02938481

TRICC1410

Details and patient eligibility

About

The T-REX study aims to clarify the actual status of metastatic lymph node (LN) distribution in colon cancer and provide reliable evidence regarding the optimal length of bowel resection and the extent of central lymph node dissection in colon cancer surgery.

Full description

In colon canser, the incidence of metastasis in the pericolic lymph nodes (LNs) located along the bowel and marginal artery is high. The optimal extent of bowel resection is closely associated with how we define 'regional' pericolic LNs, which should be resected because of the risk of metastasis. However, there are no standardised criteria for 'regional' LNs in the pericolic area.

To establish a consensus for the extent of bowel resection and appropriate central LN dissection, international prospective stdies focusing on the distribution of metastatic LNs along the bowel and the primary feeding artery are conducted.

Enrollment: 3,647 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven colon adenocarcinoma
• Pathological stage Ⅰ, Ⅱ or Ⅲ
• Potentially curative surgery
• Informed consent for observational data collection

Exclusion criteria

• Tis (mucosal cancer)
• Multiple colon cancers
• All patients with preoperative adjuvant therapy