International Registry and Biorepository for TMA(Thrombotic Microangiopathy)

Northwell Health

Status: Terminated

Conditions: Thrombotic Microangiopathy; Hemolytic Uremic Syndrome; Thrombotic Thrombocytopenic Purpura

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00593229

DK R21-71221

DK71221

Details and patient eligibility

About

This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy

Full description

Children age, 6 months - 18 years, are eligible if they have one of the following categories of thrombotic microangiopathy (TMA):(1) severe D+HUS; (2) non-familial atypical HUS; (3) familial atypical HUS; or (4) TTP

Patients are seen intially and annually thereafter

Biosamples are collected for storage annually.

Enrollment: 6 patients

Sex: All

Ages: 6 months to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Severe HUS, familial or non-familial atypical HUS, TTP

Exclusion criteria

• None

Trial design

6 participants in 4 patient groups

3

Description:

Familial atypical HUS

4

Description:

Thrombotic thrombocytopenic purpura (TTP)

1

Description:

Severe diarrhea-associated hemolytic uremic syndrome (D+HUS)

2

Description:

Non-familial atypical HUS