International T1 Multicentre CMR Outcome Study (T1-CMR)

King's College London

Status: Completed

Conditions: Chronic Kidney Diseases; Coronary Artery Disease; Cardiomyopathy; Inflammation; Heart Failure; Fibrosis

Study type: Observational

Funder types: Other

Identifiers

NCT02407197

2011-T1-MC

Details and patient eligibility

About

Myocardial fibrosis is the fundamental substrate for the development of heart failure.

Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping.

Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy.

Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE.

Primary endpoints: all cause and cardiovascular mortality.

Secondary endpoints: arrhythmic composite and HF composite endpoints.

Enrollment: 1,629 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. adults > 18 years of age
2. clinical indication for CMR
3. able to provide informed consent

Exclusion criteria

contraindications for cardiac magnetic resonance imaging due to MR unsafe devices or objects