Internet-Based Clinical Information and Blood Sample Collection From Patients With Non-Small Cell Lung Cancer Who Never Smoked Cigarettes

Vanderbilt University Medical Center

Status: Terminated

Conditions: Lung Cancer

Treatments: Other: internet-based protocol and physician referral

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01141218

VU-VICC-THO-0938

P30CA068485 (U.S. NIH Grant/Contract)

VICC THO 0938

IRB# 090568

Details and patient eligibility

About

RATIONALE: Gathering health information about patients with non-small cell lung cancer who never smoked cigarettes may help doctors learn more about the disease. Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and identify biomarkers related to cancer.

PURPOSE: This research study is studying internet-based clinical information and blood sample collection from patients with non-small cell lung cancer who never smoked cigarettes.

Full description

OBJECTIVES:

• To assess the feasibility of an internet-based protocol to collect clinical information and biological specimens from 2,000 never smokers with non-small cell lung cancer.
• To perform genome-wide association studies to identify alleles that predispose to lung cancer in patients that never smoked cigarettes.

OUTLINE:

Patients complete an internet-based questionnaire using the REDCap (Research Electronic Data Capture) survey to determine eligibility. The survey consists of a detailed smoking questionnaire and questions to collect information regarding diagnosis, sex, age, ethnicity, treatment history, and any history of previous malignancies. Blood samples are then collected from eligible patients for DNA and other laboratory analyses. Patients' pathology reports are also reviewed.

Enrollment: 88 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older
• histologically and/or cytologically proven diagnosis of non-small cell lung cancer
• never smoker, defined as having smoked less than 100 cigarettes over one's life-time
• completed survey and inclusion form
• signed informed consent

Exclusion criteria

• previous history of cancer (other than lung cancer, except for superficial skin cancers)
• living outside the United States
• patients who cannot read English (as materials will only be written in English)
• unable to understand the protocol or to give informed consent

Trial design

88 participants in 1 patient group

Never-smokers with lung cancer

Treatment:

Other: internet-based protocol and physician referral